链式CIK细胞免疫治疗联合适形调强放疗及微波热疗治疗局部晚期直肠癌临床研究

The effect of mCIK combined with IMRT and microwave hyperthermia in the treatment of locally advanced rectal cancer

目的比较链式CIK细胞免疫治疗联合适形调强放疗及微波热疗治疗局部晚期直肠癌临床疗效和安全性。方法选取90例局部晚期直肠癌患者进行前瞻性分析,分期均为Ⅲ-Ⅳ期,分为对照组和观察组,每组45例,对照组采用适形调强放疗（IMRT）联合微波热疗治疗,观察组在对照组基础上联合CIK细胞免疫治疗,比较两组患者临床疗效和不良反应发生情况。结果观察组患者2年生存率、2年局部控制率均高于对照组,2年局部复发率低于对照组,差异有统计学意义（P〈0.01）;两组放射性直肠炎发生率无明显差异（P〉0.05）;末次随访,观察组总有效率高于对照组,差异有统计学意义（P〈0.05）。结论在局部晚期直肠癌的治疗中,链式CIK细胞免疫治疗联合适形调强放疗及微波热疗可有效提高治疗有效率和2年生存率,降低复发率,且不增加不良反应发生率,具有临床应用价值。

Objective To evaluate the clinical effect of modified cytokine induced killer cells（m CIK） immunotherapy combined with intensity modulated radiation therapy（IMRT） and microwave hyperthermia in the treatment of locally advanced rectal cancer. Method 90 patients with locally advanced rectal cancer at stage III-IV were retrospectively analyzed, and were stratified as control group and study group, with 45 cases in each, given IMRT ＋ microwave hyperthermia or m CIK ＋ IMRT ＋ microwave hyperthermia, respectively, the clinical efficacy and adverse reactions were observed.Result The 2-year survival rate and 2-year local control rate were higher, while the 2-year local recurrence rate was lower in study group than those of the control group, with significant differences observed（P〈0.01）; The incidences of radiation proctitis was similar between the two groups（P〉0.05）; During the last follow-up, the overall response rate in study group was significantly higher than that of the control group（P 〈0.05）. Conclusion In the treatment of locally advanced rectal cancer, m CIK combined with intensity modulated radiation therapy and microwave hyperthermia can effectively improve the response rate and 2- year survival rate, reducing disease recurrence, without increasing the incidence of adverse reactions, which is clinically applicable.