摘要
目的研究p53和ERCC1在人结肠癌中的表达情况,并分析其与临床病理因素的关系。方法选取124例经外科手术的原发性结肠癌标本组织进行研究,采用免疫组织化学SP法染色,计算阳性表达率并分析其与临床病理因素的关系。结果 p53在人结肠癌中的阳性表达率为66.1%(82/124),明显高于癌旁正常组织(P﹤0.01),其中与TNM分期、浸润程度关联性大(P﹤0.05),而与其他临床病理因素如年龄、性别、淋巴结转移无关(P﹥0.05);ERCC1在人结肠癌中的阳性表达率为46.8%(58/124),明显高于癌旁正常组织(P﹤0.01),其中与浸润程度关联性大(P﹤0.05),而与其他病理因素如年龄、性别、TNM分期、淋巴结转移无关(P﹥0.05)。结论 p53和ERCC1在结肠癌中的表达促进其发生、发展过程。结肠癌中p53和ERCC1的表达较癌旁正常组织明显升高,可能用于结肠癌的诊断、治疗及判断预后。
Objective To study the correlation between the expression of p53 and ERCC1 in human colon carcinoma and the clinical pathological factors. Method 124 cases of primary colon cancer specimens were included in the analysis, and immunohistochemical SP staining was applied, and the correlation between positive expression rate and clinical pathological factors were analyzed. Result The positive expression rate of p53 in human colon cancer tissues was 66.1%（82/124）, which was significantly higher than that in the adjacent normal tissues（P0.01）, and a significant correlation was observed between TNM staging and infiltration（P〈0.05）, while other clinical pathological factors（such as age, sex,lymph node metastasis） were of no clinical significance（P〉0.05）; The positive expression rate of ERCC1 in human colon cancer was 46.8%（58/124）, and was also significantly higher than that in adjacent normal tissues（P〈0.01）, similar correlation was observed for infiltration（P〈0.05）, and other clinical pathological factors（age, sex, TNM staging, lymph node metastasis）（P〉0.05）. Conclusion The expression of p53 and ERCC1 in colon cancer promotes its occurrence and development process, with higher expression observed in colon cancer than in normal adjacent tissues, which may be used for the diagnosis, treatment and prognosis of colon cancer.
出处
《癌症进展》
2016年第9期892-894,共3页
Oncology Progress
