摘要
平足蛋白（PDPN）是Ⅰ型唾黏蛋白样的跨膜糖蛋白，主要表达在淋巴管内皮上，它在炎症的发生发展、淋巴管的分化与形成、肺泡的成熟和维持、肾脏滤过屏障的完整性及血小板的聚集等方面中都起着一定作用。近年来越来越多的研究证明PDPN在多种肿瘤细胞表面表达上调，且PDPN与血小板表面表达的C型凝集素样受体2（CLEC-2）间的相互作用在肿瘤的生长、迁徙与转移中有着重要作用，因此抗PDPN的功能性抗体为肿瘤患者的治疗提供了新的方向，文章针对PDPN功能的研究进展及应用前景进行综述。
Podoplanin （PDPN）, being mucin-like transmembrane sialoglycoprotein, is expressed on lymphatic endothelial cells, with its significant role in the development of inflammation, separation of blood and lymphatic circulation, platelet aggregation, integrity of the renal filtration barrier and alveolar. In recent years, many researches have demonstrated that PDPN is overexpressed on the surface of some tumor cells. The interaction between PDPN and CLEC-2 plays an important role in the development of tumor growth, migration and transfer, therefore, anti-PDPN antibody offers a new direction for the treatment of tumor patients. This paper aims at reviewing the progress and application prospect of PDPN.
出处
《肿瘤研究与临床》
CAS
2016年第9期634-637,共4页
Cancer Research and Clinic
基金
国家自然科学基金（81270593）
