染色质重塑因子1在人类恶性肿瘤中的研究进展

Progress in remodeling and spacing factor-1 in human malignant tumors

染色质重塑因子1（Rsf-1）定位于细胞核内，是最常见的扩增基因之一，最早发现于1998年，蛋白相对分子质量约为240×10^3。Rsf-1与人类蔗糖性非发酵蛋白2同源体（hSNF2H）相互作用，使细胞生长信号和生长环境发生变化，导致细胞在基因水平上失去对其生长的正常调控而异常增生，从而导致肿瘤的发生。研究表明，Rsf-1的异常表达与泌尿生殖系统恶性肿瘤、消化系统恶性肿瘤、头颈部恶性肿瘤、非小细胞肺癌及神经系统肿瘤等众多人类常见的恶性肿瘤存在密切关系，并与恶性肿瘤的预后等密切相关。

Remodeling and spacing factor-1 （Rsf-1）, firstly discovered in 1998 and located in the nucleus, is one of the most commonly amplified gene and its protein molecular weight is about 240 ×10^3. The interaction between Rsf-1 and human sucrose non-fermenting protein 2 homologue （hSNF2H） changes the cell growth signals and environment, which is inclined to cause the cells loss of the normal regulation, leading to the abnormal proliferation and occurrence of tumors. Recent study has shown that Rsf-1 is closely related to the prognosis of a lot of human malignancies, such as genitourinary system tumors, gastrointestinal tumors, head and neck cancer, non-small cell lung cancer and glioma.