TURBT治疗早期非肌层浸润性膀胱癌的效果分析

Effect of TURBT in the treatment of early non-muscle-invasive bladder cancer

目的探讨经尿道电切术(TURBT)治疗早期非肌层浸润性膀胱癌(NMIBC)的临床效果。方法选择手术治疗的早期NMIBC患者100例进行回顾性分析,根据手术方法不同,将患者分为开腹组(n=46)与TURBT组(n=54),开腹组患者采取传统开腹手术治疗,TURBT组患者采取TURBT手术治疗,对比两组患者的手术近期效果及术后复发情况。结果 TURBT组患者的手术时间、术中出血量、尿管留置时间、住院时间均明显低于开腹组,差异均有统计学意义(P﹤0.01);TURBT组患者膀胱穿孔及闭孔神经反射的发生率均高于开腹组患者,差异均有统计学意义(P﹤0.05);TURBT组患者的尿道狭窄发生率明显低于开腹组患者,差异有统计学意义(P﹤0.01);TURBT组患者的复发率、中位复发时间与开腹组比较,差异均无统计学意义(P﹥0.05)。结论 TURBT治疗早期NMIBC的效果与开腹手术相当,但是具有手术创伤小、恢复快的优势。

Objective To investigate the clinical effect of transurethral resection of the bladder tumor （TURBT） in the treatment of early non-muscle-invasive bladder cancer （NMIBC）. Method 100 patients with early NMIBC were ret-rospectively analyzed, these patients were stratified as open surgery group （n=46） and TURBT group （n=54） as per their surgery approaches, given traditional open group or TURBT, respectively, the short-term efficacy and postoperative recur-rence of the two groups were compared. Result TURBT group had shorter operative time, less intraoperative blood loss, shorter time of indwelling catheter and hospital stay than the open surgery group, with significant difference observed （P〈0.01）; While the incidences of bladder perforation and obturator nerve reflex were higher in patients receiving TURBT than those given open surgery （P〈0.05）;And a lower incidence of urethral stricture was observed in TURBT group than open surgery group （P〈0.01）;There were no significant differences regarding the recurrence rate and median recurrence time between the two groups （P〉0.05）. Conclusion The effect of TURBT on NMIBC is comparable to that of open sur-gery, with advantages of minimal invasiveness and faster recovery.