血液灌流辅助治疗急性苯化合物中毒并灼伤的临床疗效观察

Clinical study on the efficacy of hemoperfusion auxiliary in the treatment of acute benzene poisoning and burns compound

目的观察血液灌流辅助治疗急性苯化合物中毒并灼伤的临床疗效。方法选取2008年1月至2016年1月收治的急性苯化合物中毒并灼伤患者50例,依据随机数字表法分为常规治疗组(n=25)和血液灌流组(n=25),常规治疗组患者接受常规治疗,血液灌流组患者接受常规治疗联合血液灌流治疗,对两组患者的治愈、好转、死亡及并发症发生情况进行统计分析。结果血液灌流组患者的治愈率92.0%(23/25)显著高于常规治疗组80.0%(20/25)(P<0.05),死亡率4.0%(1/25)显著低于常规治疗组12.0%(3/25)(P<0.05),但两组患者的好转率4.0%(1/25)、8.0%(2/25)之间的差异无显著性(P>0.05);两组患者的并发症发生率12.0%(3/25)、8.0%(2/25)比较,差异无显著性(P>0.05)。结论采用血液灌流辅助治疗急性中毒苯化合物中毒并灼伤具有较为显著的临床疗效。

Objective To observe the clinical efficacy of hemoperfusion auxiliary in the treatment of acute benzene poisoning and burns compound.Methods A total of 50 patients with acute phenol poisoning and burns admitted into this hospital during January 2008 to January 2016 were selected for this study,these patients were divided into conventional treatment group（n=25） and hemoperfusion group（n=25） according to a random number table,patients in conventional treatment group were given with conventional treatment,patients in hemoperfusion group were given with conventional therapy combined with hemoperfusion,the rates of cure,improvement,mortality and complications in these two groups were statistically analyzed.Results The cure rate of patients in hemoperfusion group was 92.0%（23/25）,it was significantly higher than that[80.0%（20/25） ]of patients in conventional treatment group（P〈0.05）,the mortality rate 4.0%（1/25） was significantly lower than that[12.0%（3/25） ]of conventional treatment group（P〈0.05）,but the difference in improvement rate between these two groups [4.0%（1/25）,8.0%（2/25） ]was not significant（P〉0.05）.The difference in rate of complications [12.0%（3/25）,8.0%（2/25） ]between these two groups was not significant（P〉0.05）.Conclusion Hemoperfusion has more significant effect for adjuvant therapy in treatment of patients with acute phenol poisoning and burns.