丁螺环酮对女性抑郁症患者抑郁症状及性功能的影响

Study on the effect of buspirone on depressive symptoms and sexual function in female patients with depression

目的探讨丁螺环酮对女性抑郁症患者抑郁症状及性功能的影响。方法选取2014年8月至2015年8月门诊及住院的60例抑郁症合并性功能障碍的患者为研究对象,采用SAS软件产生序列号分为观察组和对照组,每组30例,对照组继续服用抗抑郁药治疗,观察组在对照组的基础上口服螺环酮治疗,两组连续治疗8周。于治疗前后采用汉密尔顿抑郁量表(HAMD)、Zung's抑郁自评量表(SDS)调查患者的抑郁症状,女性性功能指数(FSFI)调查问卷调查性功能情况,Olson婚姻质量问卷调查婚姻质量,用生活质量综合评定问卷-74(GQOL-74)调查生活质量。结果观察组治疗后的HAMD评分、SDS评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的性欲程度、阴道润滑状况、性高潮情况、性满意度均高于对照组,差异有统计学意义(P<0.05)。观察组治疗后的婚姻质量及生活质量评分均高于对照组,差异有统计学意义(P<0.05)。结论丁螺环酮不仅能够显著改善女性抑郁症患者的抑郁症状,而且也能够改善患者的性功能障碍,提高婚姻质量和生活质量。

Objective To explore the effect of buspirone on depressive symptoms and sexual function in female patients with depression.Methods A total of 60 female patients with depression and sexual dysfunction during August 2014 to August 2015 were divided into observation group and control group by using SAS software to produce sequence number,30 cases in each group,patients in control group were continuously taken with antidepressant treatment,patients in observation group were given with buspirone on the basis of the treatment in control group,and the treatment in these two groups had been continuously carried out for 8 weeks.The Hamilton Depression Rating Scale（HAMD） and Zung＇s depression self rating scale（SDS） were used to survey the depressive symptoms of patients before and after treatment,the questionnaire survey for female sexual function index（FSFI） was used for survey of sexual function,Olson marital quality questionnaire was used for marital quality,comprehensive assessment of life quality questionnaire（GQOL-74） was applied for the survey of life quality.Results After treatment,HAMD scores and SDS scores in patients of observation group were lower than those of patients in control group,and the difference was statistically significant（P〈0.05）.The degrees of sexual desire,vaginal lubrication,orgasm and sexual satisfaction in patients of observation group after treatment were higher than those of patients in control group,and the difference was statistically significant（P〈0.05）.Marital quality and life quality scores after treatment in patients of observation group were higher than those of patients in control group,and the difference was statistically significant（P〈0.05）.Conclusion Buspirone can improve the depression symptoms,and it also can improve the sexual dysfunction,marital quality and life quality of female patients with depression.