甲硝唑与雌激素联合治疗萎缩性阴道炎的疗效观察

Curative effect observation of metronidazole combined with estrogen in the treatment of atrophic vaginitis

目的探讨甲硝唑与雌激素联合治疗萎缩性阴道炎的临床疗效。方法选取2015年1月到2015年12月我院60例萎缩性阴道炎患者作为研究对象,将患者随机分为常规组(n=30)和联合组(n=30),给予常规组患者甲硝唑治疗,联合组患者在常规组患者的基础上给予雌激素治疗,对比两组患者的治疗效果及用药不良反应发生情况。结果联合组患者治疗总有效率为96.7%,高于常规组的80.0%(P<0.05)。联合组患者治疗后子宫内膜厚度(3.9±0.3)mm、表层细胞百分比(28.9±3.2)%、雌二醇水平(51.1±6.2)pmol/L与常规组的(2.6±0.3)mm、(7.6±3.1)%、(43.1±6.5)pmol/L比较,明显较高(P<0.05)。联合组患者疗后阴道p H(4.8±0.6)、卵泡刺激素水平(51.2±5.8)U/L明显低于常规组的(5.6±0.7)、(65.4±6.1)U/L(P<0.05)。联合组患者3个月复发率明显低于常规组(P<0.05)。结论临床上采取甲硝唑与雌激素联合治疗萎缩性阴道炎效果显著,能有效提升治疗效果,改善患者临床指标及相关激素水平,减少复发情况,且患者用药不良反应少,安全可靠,可在临床推广运用。

Objective To explore the clinical curative effect of combination therapy of metronidazole and estrogen on atrophic vaginitis. Methods Sixty patients with atrophic vaginitis in our hospital from January 2015 to December 2015 were selected as the research objects, the patients were randomly divided into normal group （n=30） and the combination group （n=30）, the patients in normal group were given metronidazole treatment, the combination group received estrogen therapy on the basis of normal therapy, then the curative effect of two groups and the status of the drug adverse reaction were compared. Results The total effective rate of combination group was 96.7%, which was higher than 80.0% of the normal group （P〈0.05）; the patients＂ endometrial thickness in combination group after treatment was （3.9±3.9） mm, the surface cells percentage was （28.9±3.2） %, the estradiol level was （51.1±6.2） pmol/L, which were higher than （2.6±0.3） mm, （7.6±3.1） %, （43.1±6.5） pmol/L in normal gourp （P〈0.05）; the vaginal pH in combination group after treatment was （4.8±0.6）, the follicle-stimulating hormone levels was （51.2±5.8） U/L, which were lower than （5.6±0.7）, （65.4±6.1） U/L in combination group, the difference was significant （P〈0.05）. The recurrence rate in 3 months after treatment showed significant difference in two groups （P〈0.05）. Conclusion The treatment effect of metronidazole combined with estrogen on atrophic vaginitis is obvious, it can effectively improve the curative effect, improve clinical indicators and related hormone levels, reduce the recurrence and has less drug adverse reactions, which can be popularized in clinical.