芳香烃受体信号通路与类风湿关节炎病理改变的研究进展

The roles of AhR signal pathway in alteration to pathology of rheumatoid arthritis

芳香烃受体(Aryl hydrocarbon receptor,AhR)是一种配体依赖性的转录因子,AhR信号通路在人体免疫系统功能的执行与调节中发挥着重要作用。类风湿关节炎(Rheumatoid arthritis,RA)作为一种胸腺依赖性淋巴细胞及细胞因子异常导致的炎症和以骨平衡障碍所致骨破坏为主要表现的自身免疫病,与AhR存在重要的关系。总结了近年来AhR信号通路与RA病理改变相关的研究进展。

The aryl hydrocarbon receptor（ AhR） is a ligand-depended transcription factor which plays an essential role in acting and regulating the human＇s immunology system. Rheumatoid arthritis（ RA） is described as an autoimmune chronic inflammatory disease which presents with abnormity of T cell and cytokines as well as the destruction of bone and related bone imbalance,associated with the AhR pathway. This review aims to summarize the researches about the roles of AhR signal pathway in alteration to pathology of RA and discuss the functions of this pathway in the development of RA.