通窍鼻炎颗粒联合粉尘螨滴剂治疗过敏性鼻炎的临床研究

Clinical study on Tongqiao Biyan Granules combined with Dermatophagoides Farinae Drops in treatment of allergic rhinitis

目的探讨通窍鼻炎颗粒联合粉尘螨滴剂治疗过敏性鼻炎的临床疗效。方法选取2014年10月—2015年10月在重庆市开县人民医院接受治疗的过敏性鼻炎患者88例,根据治疗方案的差别分为对照组和治疗组,每组各44例。对照组舌下含服粉尘螨滴剂,1滴/次,3次/d。治疗组在对照组基础上口服通窍鼻炎颗粒,1袋/次,3次/d。两组均连续用药21 d。观察两组的临床疗效,比较两组的症状评分和血清学指标的情况。结果治疗后,对照组和治疗组的总有效率分别为81.82%、95.45%,两组比较差异有统计学意义(P<0.05)。治疗后,两组打喷嚏、流涕、鼻塞、鼻痒评分及总分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组IL-4、IL-10、s Ig E、T-Ig E和EOS均显著下降,而IL-12和s Ig G4显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论通窍鼻炎颗粒联合粉尘螨滴剂治疗过敏性鼻炎具有较好的临床疗效,可明显改善患者临床症状,提高患者机体的免疫能力,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Tongqiao Biyan Granules combined with Dermatophagoides Farinae Drops in treatment of allergic rhinitis. Methods Patients（88 cases） with allergic rhinitis in The People＇s Hospital of Kaizhou District from October 2014 to October 2015 were enrolled in this study. According to the different treatment plan, patients were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were sublingual administered with Dermatophagoides Farinae Drops, 1 drop/time, three times daily. Patients in the treatment group were po administered with Tongqiao Biyan Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 21 d. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 95.45%, respectively, and there was difference between two groups（P〈0.05）. After treatment, the scores of sneezing, runny nose, nasal congestion, and nasal itching and the total scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, IL-4, IL-10, s Ig E, T-Ig E, and EOS in two groups were significantly decreased, but IL-12 and s Ig G4 in two groups were in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Tongqiao Biyan Granules combined with Dermatophagoides Farinae Drops has clinical curative effect in treatment of allergic rhinitis, can significantly improve clinical symptoms, and increase immune function, which has a certain clinical application value.