儿童系统性红斑狼疮早期诊断的临床体会

Children's Clinical Experience in Early Diagnosis of Systemic Lupus Erythematosus

目的:分析儿童系统性红斑狼疮(SLE)早期诊断的临床表现及实验室检查特点。方法:选取肇庆市第一人民医院收治的68例符合SLE的儿童,比较患儿的首发症状、临床表现及实验室检查资料,研究儿童SLE早期诊断依据。结果:皮肤黏膜损害与蝶形红斑患者中女性较男性高发,差异具有统计学意义(P<0.05)。女性患儿的ANA阳性率高于男性,男性患儿的抗SSB抗体阳性率高于女性,差异具有统计学意义(P<0.05)。结论:儿童SLE起病的临床表现多样,实验室检验结果多提示血液系统、肾脏功能损害,临床表现及实验室检查缺乏特异性,需要综合诊断,减少漏诊误诊。

Objective To analyze the clinical manifestations of children＇s early diagnosis of systemic lupus erythematosus.Methods 68 cases with systemic lupus erythematosus were chosen and their starting symptoms,clinical manifestation and laboratory examination data were compared.Results The results showed the patients with butterfl y erythema of skin mucous membrane injury prone to women than men,and it had statistically significant difference（P0.05）.Female children of the ANA positive rate was higher than male,male children with anti SSB antibody positive rate than women,statistically significant difference（P0.05）.Conclusion the clinical manifestations of SLE onset in children is diversiform,laboratory test results more prompt blood system,kidney damage,clinical manifestation and laboratory examination lack of specificity,and need comprehensive diagnosis and reduce misdiagnosis and misdiagnosis.