急性肺栓塞患者血清Apelin-13水平与死亡率的相关性

Correlation Analysis on Acute Pulmonary Embolism Patients Between the Level of Serum Apelin-13 and Mortality Rate

目的探讨急性肺栓塞(acute pulmonary embolism,APE)患者血清Apelin-13水平与死亡率的相关性。方法连续性纳入70例APE患者,根据28d死亡率情况分为存活组(n=46)和死亡组(n=24)。记录和分析治疗前Qanadli栓塞指数和血清Apelin-13水平。结果存活组患者Qanadli栓塞指数、Apelin-13水平明显低于死亡组,组间比较差异具有统计学意义(P<0.05)。Apelin-13早期诊断APE的曲线下面积(area under the curve,AUC)为0.826,cut-off值为85.1 ng/ml,敏感度为80.3%、特异度为81.2%。Apelin-13预测死亡事件的AUC为0.774,cut-off值为106.2 ng/ml,敏感度为82.1%、特异度为75.6%。Apelin-13与APE患者死亡事件(r=0.603,P<0.05)和Qanadli栓塞指数(r=0.614,P<0.05)成正相关。结论 APE患者血清Apelin-13水平明显上升,有助于早期诊断和病情预后评估。

Objective To evaluate the correlation analysis on acute pulmonary embolism（APE）patients between the levels of serum Apelin-13 and mortality rate.Methods Seventy APE patients were enrolled in this study and divided into two groups based on prognosis：survival group（n=46）and death group（n=24）.The levels of Qanadli index and serum apelin-13 were measured and analyzed.Results The levels of Qanadli index in survival group were lower than those in death group（P〈0.05）.Death APE patients had a higher levels of Apelin-13 in comparison with survival APE patients（P〈0.05）.The area under the curve（AUC）of Apelin-13 for APE detection was 0.826,of which cut-off value was 85.1ng/ml with 80.3% sensitivity and 81.2% specificity.The AUC of Apelin-13 for APE death prognosis was 0.774,of which cut-off value was 106.2 ng/ml with 82.1% sensitivity and 75.6% specificity.Correlation analysis showed that Apelin-13 was positively associated with death（r=0.603,P〈0.05）and Qanadli index（r=0.614,P〈0.05）.Conclusion The levels of Apelin-13 are elevated in APE patients,which may be useful for early diagnosis and prognosis.