葡萄糖6-磷酸异构酶在类风湿关节炎中的诊断价值

Diagnostic Analysis of Glucose 6-phosphate Isomerase in Patients with Rheumatoid Arthritis

目的:分析葡萄糖6-磷酸异构酶(G6PI)在类风湿关节炎(RA)中的诊断价值。方法:选取125例RA患者作为研究对象,采用酶联免疫吸附试验(ELISA)检测125例RA患者、67例其他风湿病患者、39例健康对照者的血清G6PI浓度,并作统计学分析;将RA患者的血清G6PI浓度与关节疼痛数、关节肿胀数、类风湿因子、血沉进行Spearman等级相关性分析。结果:经t或χ2检验,RA患者活动期血清G6PI浓度3.92μg/m L为阳性,G6PI阳性率(70.59%)大于其他风湿病组、健康对照组(P<0.05);RA患者的血清G6PI浓度与关节疼痛数、关节肿胀数、类风湿因子、血沉呈正相关,与关节疼痛数相关系数(r)为0.658,与关节肿胀数r为0.543,与类风湿因子r为0.769,与血沉r为0.485(P<0.05)。结论:RA患者血清G6PI浓度明显升高,可作为RA患者的诊断观察指标,对于判断RA病情进展及预后具有意义。

Objective To analyze the diagnosis value for glucose 6-phosphate isomerase （G6PI） in rheuma- toid arthritis （RA）. Methods A total of 125 cases of RA patients were selected as the research objects. The serum concertration of G6PI in 125 patients with RA, 67 other rheumatic patients and 39 cases with health peo- ple was detected by enzyme-linked-immunosorbent assay. Spearman rank correlation analysis was used to anal- yse the correlection between G6PI concertration with joint pain numbers, joint swelling numbers, rheumatoid fac- tor（RF） and erythrocyte sedimentation rate（ESR）. Results Serum concertration of G6PI in RA patients was 3.92 ~g/mL as positive cases. The positive rate in RA patients was 70.59%, greater than in other rheumatic pa- tients or healthy people. Serum concertration of G6PI in RA patients was correlated with joint pain numbers（r= 0.658）, joint swelling numbers（r=0.543） and ESR（r=0.485） Conclusion The serum G6PI concentration was significantly increased in RA patients, which could be used could be used to judge progression and prognosis of RA. as a diagnostic indicator of RA. Detection of G6PI