一种新型科罗索酸衍生物的生物催化合成

Biocatalytic Synthesis of a Novel Corosolic Acid Derivative

科罗索酸是一种五环三萜酸,因其显著的抗糖尿病活性而备受关注.通过生物催化的方法对其进行结构修饰和改造,增加科罗索酸结构多样性,为筛选结构新颖或活性更强衍生物奠定基础.使用一株植物内生真菌Umbelopsis isabellina催化合成一个新的科罗索酸衍生物,命名为2α,3β,7β-三羟基-乌苏-11-烯-28,13-内酯(2).其结构通过高分辨质谱、核磁共振等波谱技术确定.

Corosolic acid, a pentacyclic triterpene acid, attracted more and more attention because of the significant anti-diabetes activity. Biocatalysis was applied to modify the structure of corosolic acid to increase the structural diversity of corosolic acid and lay the foundation for screening derivatives with novel structure or better activity. A novel corosolic acid derivative was synthesized by endophytic fungus Umbelopsis isabellina. The structure of the new compound was established by HR-ESIMS and NMR spectrum.