摘要
目的 从循证医学的角度评价性伴侣数量与前列腺癌之间的相互关系。方法 计算机检索PubMed、Embase、中国知网、维普中文科技期刊数据库、万方数据库,查找并筛选有关性伴侣数量与前列腺癌发病的研究,浏览相关综述,同时手工检索结果中所附相似文献及参考文献,检索时限为建库至2014年12月30日。由2名系统评价员单独进行文献筛选及资料提取,采用StataSE12.0软件进行Meta分析及其他统计学分析。结果 筛选出10篇文献。整体分析结果显示性伴侣数量与前列腺癌之间存在明显关联（Z=3.04,P=0.002）,合并效应OR=1.189,置信区间（95%CI：1.064~1.329）,差别有统计学意义;性伴侣数量10人以下的合并效应OR=1.179,置信区间（95%CI：0.966~1.435）,差别无统计学意义;10~20人的合并效应OR=1.141,置信区间（95%CI：0.987~1.320）,差别无统计学意义;20人以上的合并效应OR=1.277,置信区间（95%CI：1.034~1.577）,差别有统计学意义（P=0.023）。结论 性伴侣数量是前列腺癌的重要危险因素,尤其是性伴侣人数达到20人以上时危险性增加。
ObjectiveTo evaluate the relationship between prostate cancer and the number of sexual partners based on evidence-based medicine. MethodsEligible studies on the association between the number of sexual partners and prostate cancer were searched in PubMed，Embase，CNKI，VIP and CDDB databases from the inception to Dec. 30，2014. The references of the retrieved studies and recent reviews were manually retrieved. Two reviewers independently screened the literatures and extracted the data. Meta-analysis and relevant statistical analysis were conducted with StataSE12.0 software. ResultsA total of 9 studies were included in our Meta-analysis. A clear correlation existed between the number of sexual partners and prostate cancer （Z=3.04，P=0.002），merge effect OR=1.189，confidence interval （95%CI：1.064-1.329），and the difference was statistically significant（P＜0.05）. If the number of sexual partners was less than 10，the pooled OR was 1.179，and 95%CI（0.966，1.435），showing no statistical significance（P＞0.05）. If the number of sexual partner was 10 to 20，the pooled OR was 1.141，and 95%CI （0.987-1.320），still showing no statistical significance（P＞0.05）. If the number of sexual partners was up to 20，the pooled OR was 1.277，and 95%CI （1.034-1.577），showing significant difference （P=0.023）. ConclusionThe number of sexual partners is an important risk factor for prostate cancer. When it is up to 20，the risk of prostate cancer will increase.
出处
《现代泌尿外科杂志》
CAS
2016年第12期939-942,共4页
Journal of Modern Urology
