更昔洛韦联合纳洛酮治疗小儿病毒性脑炎60例临床分析

Clinical study of Ganciclovir combined Naloxone in the treatment of 60 children with viral encephalitis

目的 探讨更昔洛韦联合纳洛酮治疗小儿病毒性脑炎的临床效果。方法 按抽签法将2012年3月~2015年8月我院收治的60例病毒性脑炎患儿随机分为实验组和对照组,每组30例。实验组采用更昔洛韦联合纳洛酮治疗,对照组采用更昔洛韦治疗,统计分析两组患儿治疗后相关临床表现的消失或减轻时间、临床疗效以及相关实验室检查结果。结果 实验组患儿相关临床表现消失或减轻时间明显短于对照组（P〈0.05）;实验组患儿的临床疗效明显优于对照组（P〈0.05）;实验组患儿的肝功能及肾功能损害情况明显优于对照组（P〈0.05）。结论 对小儿病毒性脑炎患者实施更昔洛韦联合纳洛酮治疗,可明显提高患儿的疗效,改善预后,降低出现后遗症的机会。

Objective To investigate the clinical effect of the treatment with Ganciclovir combined Naloxone on pedi- attics of viral encephalitis.Methods According to the draw method 60 children with viral encephalitis admitted in our hospital from March 2012 to August 2015 were randomly divided into experimental and control group,30 cases in each group. Statistical analysis was used to analyze the disappearance time of the related clinical symptoms,clinical effects, relevant laboratory results of patients after the treatment in the two groups.Results The time of the experimental group which was related to clinical manifestations disappeared or reduced was significantly shorter than the control group （P〈 0.05）;the clinical efficacy of the experimental group was superior than the control group （P〈0.05）;the condition of liver function and renal damage of patients in the experimental group was obviously better than that of the control group （P〈 0.05）.Conclusion Ganciclovir combined with Naloxone can significantly improve the clinical efficacy of children with viral encephalitis,and improve the prognosis and reduce the complications.