狼疮性血管炎

Vasculitis in lupus erythematosus

红斑狼疮是一种慢性自身免疫性结缔组织疾病,发病机制复杂,临床表现多样,血管炎是其中的一种重要表现。血管炎启自炎症和血栓形成,发病机制中的关键环节是内皮细胞的激活及粘附分子的表达与激活。抗血管内皮细胞自身抗体、抗磷脂抗体、抗中性粒细胞胞浆抗体、抗双链DNA抗体等直接或间接作用于血管内皮细胞,引起慢性血管壁损伤。药物与微生物也可能参与到了血管炎的发生。目前对红斑狼疮性血管炎的治疗主要是使用糖皮质激素,免疫抑制剂,抗疟药及非甾体类抗炎药等。

Lupus erythematosus （LE） is an autoimmune connective tissue disease. The pathogens is complex and clinical manifestations is diverse, vascular lesions are one of the typical symptoms. LE vasculopathy may be of inflammatory or thrombotic origin. It seems that endothelial ceils activation with pronounced expression and activation of adhesive molecules are the key factors in the patbogenesis of this disease. AECA, Antiphospholipid antibodies, ANCA, anti-dsDNA as circulating immune complexes, which directly or indirectly affect endothelial cells, causing chronic vessel wall damage. Drugs and microbes may also be involved in the occurrence of vasculitis. So far, the treatment of vasculitis in LE contains glucocorticoid, immunosuppressants, antimalarial drugs and nonsteroidal anti-inflammatory drugs , etc.