清肾颗粒联合中药保留灌肠对慢性肾衰竭肾功能及微炎症状态的影响

Effects of Qingshen Granule and Retention Enema with Traditional Chinese Medicine on Renal Function and micro-inflammatory State in Patients with Chronic Renal Failure

目的:观察清肾颗粒联合中药保留灌肠对慢性肾衰竭患者肾功能及微炎症状态的影响。方法:纳入慢性肾衰竭湿热血瘀证患者60例,按随机数字表法分为治疗组30例,对照组30例。对照组予以西医常规治疗,治疗组在此基础上加用黄苓解毒泄浊颗粒保留灌肠(1次/d,疗程4周)和清肾颗粒(10g/次,3次/d,疗程4周),分别于人院时及治疗4周后观察2组血肌酐(Scr)、肾小球滤过率估算值(eGFR)、24h尿蛋白定量(24hUP)及IL-6、α-TNF水平变化情况,并对临床疗效进行评价。结果:治疗4周后,治疗组和对照组Scr、24hUP、IL-6、α-TNF水平均明显降低、eGFR均显著升高(P<0.05),且组间比较治疗组明显优于对照组(P<0.05);治疗组有效率为76.67%,对照组有效率为53.33%,治疗组有效率明显优于对照组(P<0.05)。结论:清肾颗粒联合黄苓解毒泄浊颗粒保留灌肠能够有效降低患者Scr、24hUP、IL-6、α-TNF水平,并能提高eGFR,能够改善患者肾功能,其机制可能与抑制炎症微状态有关。

Objective： To observe the effects of Qingshen granule and retention enema with traditional Chinese medicine on renal function and micro-inflammatory state in patients with chronic renal failure.Methods： 60 patients with chronic renal failure were randomly divided into treatment group（n=30）and control group（n=30）.The control group was treated with conventional western medicine, and the treatment group was given Huangling Jiedu Xiezhuo granule retention enema （one times a day）and Qingshen granule（10g/time ,3times/day, 4weeks a treatment course） based on western medicine, the therapeutic course for all was 4 weeks. Scr： eGFR, 24hUP, IL-6 and TNF-α were detected when admission and 4 weeks after treatment. Meanwhile, the clinical efficacy was evaluated. Results： After treatment for 4 weeks, Ser, 24hUP, IL-6 and TNF-α in both groups were decreased significantly（P〈0.05）, while The level of eGFR increased obviously（P〈0.05）, with statistical significance between the two groups（P〈0.05） ; the total effective rate of the treatment group was 76.67%, which was significantly better than than the control group（53.33%）. Conclusion： The Qingshen granule and retention enema with traditional Chinese medicine could effectively reduce the levels of Scr, 24hUP, IL-6 and TNF- α, improve eGFR in patients, thus to improve renal function by means of inhibiting micro-inflammatory state.