柴胡加龙骨牡蛎颗粒剂治疗脑卒中后抑郁症临床观察

Clinical Observation of Radix Bupleuri Add Keel Oyster Granules in Treating Post-Stroke Depression

目的:观察柴胡加龙骨牡蛎颗粒剂治疗脑卒中后抑郁症的疗效。方法:选取脑卒中后抑郁症患者134例,随机分为治疗组68例,对照组66例,2组均给予常规治疗,治疗组口服中药柴胡加龙骨牡蛎颗粒剂,对照组口服西药西酞普兰片,2组连续服用2周,在第1周、第2周分别进行HAMD抑郁量表评分、神经功能缺损程度评分(NIHSS)、日常生活活动能力评分(MBI)、中医症候评分。结果:2组NIHSS评分比较差异无显著性((P>0.05),2组在第2周MBI评分比较差异有显著性(P<0.05),2组在第2周HAMD抑郁量表评分和中医症候评分比较差异有显著性(P<0.01)。结论:柴胡加龙骨牡蛎颗粒剂可以有效治疗脑卒中后抑郁症,并可缓解抑郁症状,改善神经功能,提高生存质量。

Objective： To observe the cure effect of Radix bupleuri add keel oyster granules on post-stroke depression.Methods： 134 cases of post-stroke depression were randomly divided into observation group and control group. The two groups were given conventional treatment of cerebral infarction. The observation group were given Radix bupleuri add keel oyster granules and the control group were given citalopram. Treatment was for 2 weeks. After 1 and 2 week of treatment, the two groups were assessed with Hamilton Depression（HAMD）Scale and National Institute of Health Stroke Scale（NIHSS）and activity of daily living（Modified Barth Index, MBI）and traditional Chinese medicine Syndrome score. Results： There were no significant differences in NIHSS and MBI between two groups（P〉0.05）. However, in 2th weeks after treatment there were significant difference in MBI（P〈0.05）. There were significant difference statistically in HAMD scale and TCM syndrome score after two weeks of treatment between two groups（P〈0.01）. Conclusion： Radix bupleuri add keel oyster granules in the treatment of post-stroke depression has significant therapeutic effect, and also can alleviate depression symptoms, improve neurologic function and quality of life.