吸烟与脑膜瘤关系的荟萃分析

Association between Smoking and Meningioma Risk:A Meta-Analysis

目的通过系统回顾和荟萃分析研究吸烟与脑膜瘤的相关关系。方法在线检索与主题相关的研究文献,对符合条件的研究进行质量评价和数据提取,采用Stata 12.0软件进行荟萃分析。结果共纳入符合条件的研究文献12篇。Meta分析结果显示脑膜瘤病组与对照组人群中吸烟率的优势比差异无统计学意义（OR=1.03,95%CI：0.95~1.12,P=0.513）,男性（OR=1.22,95%CI：1.00~1.49,P=0.046）与女性（OR=0.89,95%CI：0.80~1.00,P=0.046）脑膜瘤病组与对照组之间吸烟率的差异均有统计学意义。在平均每天吸烟包数!烟龄≥13时,脑膜瘤病组与对照组人群中吸烟率的优势比差异有统计学意义（OR=1.20,95%CI：1.04~1.38,P=0.011）,男性脑膜瘤病组与对照组之间吸烟率的差异有统计学意义（OR=1.40,95%CI：1.10~1.77,P=0.006）,而女性无统计学差异（OR=1.02,95%CI：0.85~1.22,P=0.85）。分别以研究类型（病例对照研究/队列研究）、研究种族、对照人群来源进行亚组分析,结果显示,曾经吸烟与脑膜瘤之间的关联无统计学差异,P〉0.05。结论根据现有资料表明,曾经吸烟与脑膜瘤发生没有相关性,而长期大量吸烟有可能是脑膜瘤发生的危险因素之一,对于男性尤为显著,对女性来说,曾经吸烟可能是脑膜瘤发生的一个保护性因素,长期大量吸烟没有相关性。

Objective To evaluate the potential influence of smoking to the development of meningioma by an meta-analysis. Method The follow-up research literature related to theme was retrieved online,and the meta-analysis of the data extracted onto a standard form was conducted by Stata 12. 0 software. Results A total of 12 studies met the requirements were enrolled. The aggregated results showed there was no difference of the prevalence of smokers in meningioma patients and normal controls（ OR = 1. 03,95% CI： 0. 95 ~ 1. 12,P = 0. 513）. The risks estimates were 1. 22（ 95% CI： 1. 00 ~ 1. 49,P = 0. 046）,0. 89（ 95% CI： 0. 80 ~ 1. 00,P = 0. 046）,1. 40（ 95%CI： 1. 10 ~ 1. 77,P = 0. 006）,1. 02（ 95% CI： 0. 85 ~ 1. 22,P = 0. 85） and for men,women,ever smoking and heavy smoking,respectively. The pooled estimated risks associated with heavy smoking for meningioma were 1. 20（ 95% CI： 1. 04 ~ 1. 38,P = 0. 011）. Subgroup analysis showed that no significant association between meningioma and smoking in the subgroup analysis of study type,control type and different race（ P 〉 0. 05）. Conclusions Our meta-analysis suggests that there is no association between ever smoking and the risk of meningioma. However,the status varies significantly by gender with men at greater risk when heavy smoking and with women at reduced risk when ever smoking.