抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响

Effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of TNF-α,CG and CA-199 in elderly patients with pulmonary tuberculosis

目的探讨抗结核药物肝损害对老年肺结核患者外周血肿瘤坏死因子-α(TNF-α)、甘胆酸(CG)及糖类抗原199(CA-199)水平的影响及与肝损害相关指标的相关性。方法 34例因服用抗结核药物出现药物肝损害肺结核患者设为观察组,32例老年健康人群作为对照组。结果观察组患者血清中TBIL、ALT及ALP水平显著高于对照组(P<0.05);观察组患者血清中TNF-α、CG及CA-199水平显著高于对照组(P<0.05)。观察组患者血清中TNF-α、CG及CA-199水平与ALT均呈正相关(P<0.05)。结论抗结核药物肝损害可促进老年肺结核患者血清中TNF-α、CG及CA-199的表达。

Objective To explore the effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of tumor necrosis factor-α（ TNF-α）,cholylglycine（ CG） and carbohydrate antigen 199（ CA-199） in elderly patients with pulmonary tuberculosis and its correlation with liver damage indexes. Methods A total of 34 pulmonary tuberculosis patients with hepatic lesion caused by anti-tuberculosis drugs were designed as observation group,and 32 normal elderly people were selected as control group. Results Serum levels of TBIL,ALT and ALP in the observation group were significantly higher than those in the control group（ P〈0. 05）. In the observation group,the levels of serum TNF-α,CG and CA-199 were significantly higher than those in the control group（ P〈0. 05）.In the observation group,serum TNF-α,CG and CA-199 levels were positively correlated with ALT（ P〈0. 05）. Conclusion Hepatic lesion caused by anti-tuberculosis drugs can promote the expression of serum TNF-α,CG and CA-199 in elderly patients with pulmonary tuberculosis.