阿昔洛韦联合微波治疗女性复发性生殖器疱疹对患者炎性因子和免疫功能的影响

Effects of acyclovir combined with microwave therapy on inflammatory factors and immune function of female patients with recurrent genital herpes

目的研究阿昔洛韦联合微波治疗对女性复发性生殖器疱疹患者炎性因子和免疫功能的影响。方法女性复发性生殖器疱疹患者96例,接受单纯阿昔洛韦治疗的患者48例作为对照组,接受阿昔洛韦联合微波治疗的患者48例作为观察组,比较2组治疗效果,并测定其炎性因子[肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)、白介素-6(IL-6)]水平及免疫功能(IgA、IgM、IgG、CD_3^+、CD_4^+、CD_8^+)变化。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后TNF-α、IL-4、IL-6、IgA、IgM、IgG、CD_4^+、CD_8^+水平均优于对照组(P<0.05)。结论对女性复发性生殖器疱疹患者的治疗,在阿昔洛韦治疗基础上联合微波治疗的疗效显著,可缓解患者的炎症反应,同时可提高其免疫功能指标,值得临床大力推荐。

Objective To observe the effects of acyclovir combined with microwave therapy on inflammatory factors and immune function of female patients with recurrent genital herpes. Methods Ninety- six female patients with recurrent genital herpes who were treated in our hospital from January 2014 to January 2015 were randomly divided into two groups：control group（ n = 48） and observation group（ n = 48）. The patients in control group were treated by aciclovir only,however,the patients in observation group were treated by acyclovir combined with microwave therapy. The therapeutic effects were observed for both groups,moreover,the changes of levels of inflammatory factors including tumor necrosis factor- α（ TNF-α）,interleukin- 4（ IL-4）,interleukin- 4（ IL-6） and immunologic factors including IgA,IgM,IgG,CD_3~＋,CD_4~＋,CD_8~＋were observed and compared between two groups. Results The effective rate in observation group was 97. 92%（ 46 /48）,which was significantly higher than that [79. 07%（ 38 /48） ]in control group（ P〈 0. 05）. After treatment the levels of TNF-α,IL-4,IL-6,IgA,IgM,IgG,CD_4~＋,CD_8~＋in observation group were superior to those in control group（ P〈 0. 05）. Conclusion The acyclovir combined with microwave therapy has obvious therapeutic effects on recurrent genital herpes in female patients,which can relieve the inflammatory reactions of patients,at the same time,which can enhance patients ＇immune function parameters,thus,which is worth using widely in clinical practice.