Amberlyst-15催化C(sp^3)—H对靛红类化合物的加成反应

The Nucleophilic Addition Reactions of C(sp^3) —H to Isatins Catalyed by Amberlyst-15

以Amberlyst-15为催化剂,甲基吡啶类化合物中的C(sp^3)—H键对靛红类化合物经加成反应合成了24个3-羟基-2-吲哚酮类化合物(3a^3x),其中3u^3x为新化合物,其结构经1H NMR,13C NMR,IR和HR-MS(ESI)表征。催化剂Amberlyst-15循环使用8次,不影响反应收率。

Twenty four 3-hydroxy-2-oxindoles（3a - 3x） were synthesized by the nucleophilic addition reactions of C （sp3）--H bond in methyl pyridine compounds to isatins, using Amberlyst-15 as catalyst. Among them, 3u - 3x were novel compounds and the structures were characterized by 1H NMR, 13C NMR, IR and HR-MS（ESI）. The catalyst can be reused for eight times without significant loss of its catalytic activity.