热疗联合替吉奥单药治疗老年晚期胃癌的临床观察

Clinical Observation of Hyperthermia Combined with S-1 in the Treatment of Elderly Patients with Advanced Gastric Cancer

目的探讨替吉奥单药联合热疗技术治疗老年晚期胃癌患者的临床效果。方法以我院接诊的76例晚期胃癌老年患者作为研究对象,随机分为观察组和对照组各38例,观察组患者在口服替吉奥胶囊治疗的基础上采取热疗治疗,对照组患者通过口服替吉奥胶囊化疗治疗,比较两组患者治疗有效率、不良反应及治疗后生活质量评分。结果经过临床观察及治疗后的随访调查,可知观察组治疗有效率(57.9%)显著高于对照组(36.8%),观察组治疗过程中不良反应情况明显优于对照组,并且观察组患者治疗后的生活质量评分(49.13±3.12,61.41±6.72,72.16±2.37,82.24±5.96)显著高于对照组(50.29±3.34,53.26±5.41,60.15±2.02,69.34±5.47),差别均有统计学意义(P<0.05)。结论替吉奥单药联合热疗技术治疗老年晚期胃癌患者的临床效果显著,治疗过程中不良反应较少,减轻了患者在治疗过程中受到的痛苦,提高了服务水平及患者的满意度,值得在临床推广应用。

Objective To investigate the clinical effect of S-1 combined with hyperthermia technology in treating elderly patients with advanced gastric cancer. Methods 76 cases of advanced gastric carcinoma in the elderly patients as the research object were randomly divided into observation group（ n = 38） and control group（ n = 38）, patients in observation group received oral S-1 capsule and treated with hyperthermia, the control group received only oral S-1 capsule, the efficiency, adverse reactions after treatment and quality of life score of patients were compared. Results By the follow-up survey after the clinical observation and treatment,result showed that the efficiency of observation group（57.9%） was significantly higher than that of control group （36.8%）, the adverse reactions of the observation group was significantly less than the control group, and observation group have a better quality of life score and was significantly higher than that of control group （P〈0.05）. Conclusion S-1 combined with hyperthermia in the treatment of elderly patients with advanced gastric cancer have a significantly clinical effect,the effective rate of the treatment is high, with less adverse reaction, reducing the patients＇ pain in the treatment process and improving patients＇ satisfaction,which is worth clinical application.