体外仿生大鼠胃的功能性材料的实用性研究

Practicability Study of the Functional Silicone Materials Used for Building the in vitro Rat Stomach

优选适合制备体外仿生大鼠胃柔性模型的功能性硅胶材料。采用四种不同硬度的功能性硅胶材料制作成三种厚度的硅胶片,并制作了相应的大鼠胃柔性模型,利用色差仪、质构仪、拉压力试验机以及灌胃实验对样品的透明度、延展性和拉伸特性进行表征。结果表明:在相同硬度下,硅胶片的透明度和延展性随着其厚度的增加而递减;而在相同厚度下,不同硬度硅胶片的透明度差异不大,但其最大拉伸形变量和延展性随硬度增大而减小。其中,硬度为10A的功能性硅胶Dragon Skin的半透明程度最高、延展性最好、抗撕扯、易回弹,且具有一定的容受性舒张的功能,因此适用于制作成体外仿生大鼠胃柔性模型。模型的前胃部分厚度定为0.32 mm,腺胃部分厚度定为0.46 mm。

Silicone materials with four kinds of hardnesses were studied in this work. They were used to make sheets and in vitro rat stomach with three kinds of thicknesses. Their transparency, ductility and tensile properties were evaluated. The ductility of the sheets was reduced as the thickness and hardness was increased. The silicone named Dragon Skin（10A）, which has the best field of view, high tear strength, good elasticity and some receptive relaxation, could apply to the making of the in vitro rat stomach. As the transparency was influenced much by the thickness, affected little by hardness, the thickness of the forestomach and the glandular stomach could be set as 0.32 and 0.46 mm.