盐酸氯卡色林的合成研究进展

Progress in synthesis of lorcaserin hydrochloride

目的:分析现有的氯卡色林合成方法以确定适合工业化生产的路线。方法:总结氯卡色林的合成路线。结果:方法一原料易得,条件温和,总收率较高。结论:综述并比较了现有的氯卡色林合成工艺,方法一更加适于工业化生产。

Objective： To analyze the existing synthetic routes of lorcaserin hydrochloride and determine the suitable route for industrial production. Methods： Various synthetic processes of lorcaserin were summarized.Results： It was shown that the reaction conditions of route 1 were moderate and its total yield was higher in synthesis of lorcaserin hydrochloride. Conclusion： Compared with other routes for synthesizing lorcaserin hydrochloride,the process in route 1 is easily to be scaled up.