脂肪乳剂在心血管系统药物中毒救治中的研究进展

Research Progress of Lipid Emulsion in the Treatment of Cardiovascular Drugs Poisoning

心血管系统药物是临床常用药，中毒危害大，可出现顽固性休克及心脏骤停。过去脂肪乳剂主要用于脂溶性局麻药中毒的解毒，近年来脂肪乳剂用于心血管系统药物中毒方面的研究及临床报道也越来越多。本文重点介绍脂肪乳剂在心血管系统药物中毒救治中的研究现状、相关解毒机制、治疗方案及不良反应。

Cardiovascular drugs are commonly used in clinical medicine, which can cause refractory shock and cardiac arrest when poisoning. Lipid emulsion was mainly used for detoxification of lipophilic anesthetics poisoning in the past. Recently more and more studies and clinical cases suggest that lipid emulsion can be adopted as one of therapies for cardiovascular drugs poisoning. Now we review and focus on the research status of the lipid emulsion in the treatment of cardiovascular drugs poisoning, the related mechanisms of detoxifieation, therapeutic regimen and adverse effect.