miRNA在脓毒症中调控TLRs信号通路的研究进展

Research progress of miRNAs regulating TLRs signaling pathway in sepsis

脓毒症（sepsis）是指由感染引起的全身炎症反应综合征。在ICU中脓毒症是危重患者的主要死亡原因之一，并且其发病率和病死率在全球范围内逐年递增。据统计，在中国，脓毒症在ICU中的发病率为8．68％，病死率可高达44．7％。因此，脓毒症成为重症医学领域亟待攻克的难题之一。目前，脓毒症发病机制尚不清楚，主要与过度炎症反应和免疫功能紊乱有关。微小RNAs（miRNAs）作为重要的免疫调控因子，可通过TLRs／NF—κB信号通路参与固有免疫调控，在脓毒症发病过程中发挥重要作用。本文就脓毒症中miRNAs参与TLRs信号通路的研究进展作一综述。

Sepsis refers to the infection caused by systemic inflammatory response syndrome. Sepsis is one of the leading causes of death in critically ill patients in the ICU and its morbidity and mortality are increasing year by year globally. According to statistics, in China, the incidence of sepsis in ICU is 8.68% and the mortality rate can be as high as 44. 7% , therefore, severe sepsis in the field of medicine to become one of the problems to be overcome. MicroRNAs （miRNAs） play an important role in the pathogenesis of sepsis through the TLRs / NF-κB signaling pathways, which play an important role in immune regulation. In this review, the progress of miRNAs involved in TLRs signaling pathway in sepsis is reviewed.