复发性口腔溃疡患者唾液中TNF-α及IL-6含量及临床意义

Content and clinical significance of interleukin-6 and tumor necrosis factor-α of saliva in patients with recurrent aphthous ulceration

目的探讨复发性口腔溃疡(recurrent aphthous ulceration,RAU)患者唾液中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及白细胞介素6(interleukin-6,IL-6)含量变化及临床意义。方法选取RAU患者30例,其中溃疡期组18例,间歇期组12例;30例健康志愿者为正常对照组。采用酶联免疫吸附测定法检测3组唾液中的TNF-α及IL-6含量。结果 3组TNF-α含量差异有统计学意义,溃疡期组和间歇期组高于对照组,而间歇期组高于溃疡期组(P<0.05)。3组IL-6差异无统计学意义(P>0.05)。RAU患者唾液中TNF-α与IL-6含量变化无相关性(r=-0.090,P=0.638)。结论唾液中TNF-α含量升高可能是RAU的主要发病因素之一。

Objective To evaluate salivary interleukin（ IL）-6 and tumor necrosis factor（ TNF）-αof patients with recurrent aphthous ulceration（ RAU）. Methods A total of 30 patients with RAU were selected as the research subjects,including 18 cases of ulcer and 12 cases of intermittent period. Thrity healthy volunteers were used as normal control. TNF-α and IL-6 levels were determined by using enzymelinked immunosorbent assay. Results The content difference of TNF-α in the 3 groups was statistically significant,the ulcer phase and the interval group were higher than those in the control group,while the interval group was higher than that of the ulcer group,the difference was statistically significant（ P〈0. 05）. In the IL-6 content,there was no significant difference between the 3 groups（ P〉0. 05）. There was no correlation between the levels of TNF-α and IL-6 in saliva of RAU patients（ r =-0. 090,P =0. 638）. Conclusion TNF-α content increased in saliva may be one of the main risk factors of RAU etiology.