Lauren分型与胃癌临床病理特征及预后的相关性研究

Clinicopathological characteristics and prognosis of gastric carcinoma by Lauren classification

目的：探讨Lauren分型与胃癌临床病理特征及预后的相关性。方法：收集2009年1月～2010年12月在皖南医学院弋矶山医院就诊的791例胃癌患者的病理资料，其中弥漫型胃癌（DGC）331例，肠型胃癌（IGC）355例，混合型（MGC）105例。分析DGC与IGC患者临床病理特征与预后的关系。结果：DGC与IGC患者在性别、年龄、肿瘤最大径、T分期、N分期、TNM分期上差异均有统计学意义（ P＜0．05）。单因素生存分析显示年龄、肿瘤最大径、肿瘤部位、T分期、N分期、TNM 分期和Lauren分型是影响胃癌患者预后的相关因素。多因素生存分析显示：仅年龄、肿瘤部位、N分期、TNM分期和Lauren分型是影响胃癌患者预后的独立影响因素。生存函数显示：DGC的5年生存率低于IGC（32．4％vs．47．2％，P＜0．001）。结论：Lauren分型与胃癌临床病理特征及预后关系密切。

Objective：To explore the clinicopathological characteristics and prognosis of gastric carcinoma by Lauren classification .Methods：The patholog-ical data were collected from 791 cases of gastric carcinoma admitted to our hospital between January 2009 and December 2010,including diffuse-type gas-tric carcinoma（DGC） in 331 cases,intestinal-type（IGC） in 355 and mixed-type（MGC） in 105,and analyzed pertaining to clinicopathological characteris-tics and prognosis.Results：DGC type was significantly different from IGC type concerning the patient′s age,gender,tumor size,T-staging,N-staging and INM-staging by Lauren classification（ P〈0.05） .Univariate survival analysis revealed that prognostic factors for gastric carcinoma patients were associated with age,tumor size,tumor location,T-staging,N-staging,TNM-staging and Lauren classification.Contrarily,multivariate analysis indicated that only age, tumor location,N-staging,TNM-staging and Lauren classification were independent factors for patients′prognosis.Survival function showed that DGC type had lower rate of 5-year survival than IGC patients（32.4%vs.47.2%,P〈0.001）.Conclusion：Lauren classification is closely related with clinicopathlogical characteristics and prognosis of gastric carcinoma .