28例造血干细胞移植术后早期感染的临床研究

Nosocomial infection in early stage following hemopoietic stem cell transplantation: Clinical report and analysis in 28 cases

目的：探讨造血干细胞移植（ HSCT）术后早期感染的临床特点。方法：回顾性分析2012年4月～2015年10月我院收治的28例各种类型造血干细胞移植病例早期感染的发生和治疗情况。结果：28例患者在移植早期27例（96．4％）发生了不同程度的感染，发生中位时间6．9 d。异基因造血干细胞移植（Allo-HSCT）与自体造血干细胞移植（Auto-HSCT）发生感染率无显著差别，重症感染率差异有统计学意义（ P＜0．05）。结论：HSCT后早期感染发生率高，临床尤其要注重Allo-HSCT后早期感染的预防、鉴别和治疗。

Objective：To investigate the ward infection features in patients in the early stage following hematopoietic stem cell transplantation （HSCT）. Methods：The incidences and management strategies were reviewed in 28 cases complicated with ward infections in the early stage after hematopoietic stem cell transplantation between April 2012 and October 2015.Results：Infections occurred in 27 of 28 cases（96.4%） following transplantation.The median time for infection was 6.9 days（mean：10.8 d）.The infection was not significantly different in patients received Allo-HSCT or Auto-HSCT,yet was signifi-cant in cases with severe infection（P〈0.05）.Conclusion：Infection is a major complication in early stage following HSCT,and patients received Allo-HSCT may be complicated with severe infection,which requires special attention,identification and timely management.