2013—2015年上海浦东新区流感样病例病毒谱特征分析

The pathogen spectrum characteristics of influenza-like illness( ILI)in Pudong New Area (2013—2015)

目的 了解上海市浦东新区流感样病例病毒谱特征,为科学有效的防控措施提供依据。方法 2013—2015年采集7家医疗机构流感样病例标本,进行人流感病毒、人腺病毒、鼻病毒、人副流感病毒、呼吸道合胞病毒、人冠状病毒、人偏肺病毒和人博卡病毒检测。结果 3年共2 131例流感样病例纳入监测,年龄中位数33岁;任一病毒阳性率为35.19%（750/2 131）,其中单一病毒感染占90.80%（681/750）,混合感染占9.20%（69/750）。单一病毒感染中,人流感病毒阳性率最高（17.55%,374/2 131）,以A（H3N2）型（53.74%,201/374）为主;其次是鼻病毒（4.36%,93/2131）。任一病毒阳性率高峰在2014年1月（68.89%,31/45）和2015年1月（57.26%,71/124）。人流感病毒在冬季（12-2月）和夏季（7-9月）为优势病毒,鼻病毒在春季（3-6月）和秋季（10-11月）为优势病毒。结论 监测期间人流感病毒为该区流感样病例的优势病毒,全年呈现冬季和夏季2个流行高峰。除了人流感病毒,流感样病例也由其他呼吸道病毒引起,尤其在流感非流行季节。

Objective To understand the pathogen spectrum of ILI cases , and provide scientific basis for prevention and control measures. Methods From 2013 to 2015, samples of ILI cases in 7 hospitals were collected, and were conducted to test influenza virus, rhinovirus, adenovirus, parainfluenza vims, respiratory syncytial vims, human coronavirus, human metapneumovirus and Boka vims. Results From 2013 to 2015 , a total of 2131 ILI cases were enrolled, with a median age of 33 years old. The positive rate of any one of the viruses was 35. 19% （750/2131） , in which single infections accounted for 90. 80% （681/750） and co - infections accounted for 9. 20% （69/750）. In single infections, the positive rate of influenza was the highest （17. 55% , 374/2131） , in which A （ H3N2） type ranked as the first （53. 74% , 201/374） ; followed by rhinovirus （4. 36% , 9 3 /2 131） . The epidemic peak of any one of the viruses was in January, 2014 （68. 89% , 31/45） and January, 2015 （57.26%, 71/124）. Influenza vims was the dominant pathogen in winter （12-2 months） and summer （7-9 months） , rhinovirus was the dominant pathogen in spring （3-6 months） and autumn （10-11 months）. Conclusions Influenza was the dominant pathogen of ILI cases in Pudong New Area during the surveillance period. It peaked twice annually in winter and summer. Beside influenza, other respiratory viruses, such as rhinovirus also contributed to ILI cases, especially during the non - epidemic seasons of influenza.