复发性胶质母细胞瘤的研究进展

Research progress on recurrent glioblastoma

胶质母细胞瘤(GBM)是成人最常见且恶性程度最高的原发性颅内肿瘤,即使采用手术、放射治疗和化学治疗等综合治疗,GBM患者仍极容易复发且很快死于肿瘤。近年来,复发性GBM的生物学基础知识才渐渐浮现出来。该文回顾了目前对复发性GBM的研究成果,并且提出能否通过治疗来改变肿瘤内部的异质性、分子特性和GBM的生长方式,在某种程度上来帮助我们制定治疗策略。通过描述和预测复发性GBM在治疗过程中所引起的变化有助于将GBM控制在慢性疾病的状态。

Glioblastoma （GBM）is the most common malignant primary intracranial tumor in adults.GBM is likely to recur and leads to death even after combined treatment of surgery,radiotherapy and chemotherapy. In recent years,fundamental biological knowledge of recurrent GBM has been gradually understood.Here,current research progress on recurrent GBM was summarized to investigate whether intra-tumor heteroge-neity,molecular traits and growth pattern of GBM can be changed by clinical interventions,which provides certain evidence for establishing therapeutic regime. Description and prediction of the changes of recurrent GBM during the course of treatment contributes to maintaining the chonic state of GBM.