孤独症谱系障碍儿童的局部脑血流灌注特点研究

Characteristics of regional cerebral blood flow in children with autism spectrum disorder

目的探讨孤独症谱系障碍(ASD)儿童局部脑血流灌注(rCBF)的特点。方法采用单光子发射型计算机断层显像仪(SPECT)对66例ASD患儿(男56例、女10例)的rCBF进行显像,观察rCBF的变化。结果 66例中65例(98.5%)出现rCBF异常,60例(92.3%)有rCBF降低,5例(7.69%)除了有某个区域rCBF降低,也有其他区域rCBF增高的情况。rCBF降低的发生部位集中于颞叶(41.2%)和海马回(42.9%)。个体rCBF异常部位数量以2个或2个以上多见。结论 ASD患儿大多数存在rCBF异常,以rCBF降低为主,发生部位以颞叶及海马回为主,且单发少见。

Objective To evaluate the characteristics of regional cerebral blood flow （rCBF）in chil-dren diagnosed with autism spectrum disorder （ASD）. Methods The changes of rCBF in 66 ASD affected children,56 male and 10 female,were observed by using single photon emission computed tomography （SPECT）. Results Among 66 cases,65 （98.5%）presented with abnormal rCBF including 60 （92.3%） with rCBF decline and 5 cases （7.69%）with rCBF elevation in certain regions and rCBF reduction in other regions. The rCBF decline mainly occurred at the temporal lobe （41.2%）and hippocampal gyrus （42.9%）.For each individual,rCBF abnormality was primarily observed at 2 sites or above. Conclusions A majority of ASD affected children present with rCBF abnormality,primarily rCBF decline at the temporal lobe and hipp-ocampal gyrus. rCBF abnormality occurring at a single site is rarely seen.