羊膜腔灌注术治疗未足月妊娠羊水过少的疗效观察

Amnioinfusion in treatment of oligohydramnios in women with preterm pregnancy

目的探讨羊膜腔灌注术在治疗未足月妊娠羊水过少的临床疗效和安全性。方法选择未足月妊娠诊断羊水过少的孕妇98例,以其中行羊膜腔灌注术治疗的48例为观察组、行静脉补液治疗的50例为对照组,比较2组的妊娠结局、羊水指数变化及孕龄延长时间以及新生儿结局。结果观察组经阴道顺产比例、治疗结束时和治疗后1周羊水指数、孕龄延长时间、孕至35周以上分娩比例及新生儿体质量均较对照组增加,新生儿转入ICU比例较对照组低(P均<0.05);2组胎儿畸形检出率、活产儿比例以及胎膜早破、羊水混浊、新生儿窒息比例比较差异均无统计学意义(P均>0.05)。结论羊膜腔灌注术可有效增加未足月妊娠羊水过少孕妇的羊水指数、延长孕龄,安全性高。

Objective To evaluate the clinical efficacy and safety of amnioinfusion in the treatment of oligohydramnios for women with preterm pregnancy. Methods Ninety eight preterm pregnancy patients diagnosed with oligohydramnios were collected in this investigation. In the observation group,48 patients received amnioinfusion,and the remaining 50 patients received intravenous fluid infusion in the control group.The pregnant outcomes,variation of amniotic fluid index,prolonged gestational age and neonatal outcomes were statistically compared between two groups. Results Compared with the control group,the percentage of transvaginal natural birth,variation of amniotic fluid index upon the completion of treatment and one week after treatment,prolonged gestational age,the percentage of childbirth in women with over 35-week pregnancy and neonatal weight were significantly improved （all P〈0.05 ）,whereas the percentage of newborns transferred to NICU was considerably decreased in the observation group （all P〈0.05 ）. The detection rate of fetal abnormality,the percentage of live birth,premature rupture of membrane,amniotic fluid turbidity and the percentage of neonatal asphyxia did not significantly differ between two groups （all P〉0.05 ）. Conclusions Amnioinfusion is a safe treatment of oligohydramnios in preterm pregnancy women,which can significantly increase the amniotic fluid index and prolong the gestational age.