前列地尔对糖尿病肾病患者尿蛋白的影响

目的：探讨前列地尔对糖尿病肾病患者尿蛋白的影响.方法：选取2013年1月—2015年1月我院收治的糖尿病肾病患者100例,随机分为2组,观察组和对照组,每组50例.对照组给予常规的皮下注射胰岛素降压、降血糖治疗,观察组在常规治疗的基础上给予前列地尔配合治疗,比较两组患者临床效果.结果：经治疗后,两组患者的尿总蛋白、尿微量白蛋白、血清促炎因子TNF-a、IL-6、空腹血糖（FBG）、餐后血糖（PBG）、总胆固醇（TC）、甘油三酯（TG）浓度均明显降低（P〈0.05）,并且观察组的降低程度比对照组明显,两组比较具有统计学意义（P〈0.05）.结论：前列地尔可有效降低糖尿病肾病患者的尿蛋白以及血清炎症因子含量,降低患者血糖水平,调整患者的糖脂代谢,改善患者肾功能,阻滞机体炎症反应的发生,改善患者肾功能,值得临床推广使用.

Objective： To investigate the effects of alprostadil on urinary protein in patients with diabetic nephropathy. Methods： January 2013 - diabetic nephropathy in January 2015 in our hospital 100 cases were randomly divided into two groups, the observation group and the control group, 50 cases in each group. The control group received conventional subcutaneous insulin blood pressure, lowering blood sugar treatment, observation group was treated with alprostadil treatment on the basis of conventional therapy, the clinical outcomings were compared. Results： After treatment, the two groups of patients with total urinary protein, urinary albumin, serum proinflammatory cytokine TNF-a, IL-6, fasting blood glucose （FBG）, postprandial blood glucose （PBG）, total cholesterol （TC）, triglyceride （TG） concentrations were significantly lower （P 〈0.05）, and the extent of the observation group was significantly lower than the control group, the two groups was statistically significant （P 〈0.05）. CONCLUSION： Alprostadil can effectively reduce urinary protein and serum inflammatory cytokines in diabetic patients with renal disease, lower blood sugar levels in patients, adjust the patient’s glucose and lipid metabolism, improve renal function, blocking the body’s inflammatory response occurs, improve renal function, worthy of clinical use.