再生障碍性贫血患者治疗前后血清IL-2IL-4和VEGF水平检测的临床意义

目的：探讨了再生障碍性贫血患者治疗前后血清IL-2、IL-4和VEGF水平的变化及临床意义.方法：应用酶联结对31例再生障碍性贫血患者进行了血清IL-2、IL-4和VEGF水平检测,与35名正常人做比较.结果：再生障碍性贫血患者治疗前血清IL-2、VEGF水平非常显著地低于正常人组（p〈0.01）,而IL-4水平又非常显著地高于正常人组（p〈0.05）,经3个月治疗后与正常人比较仍有显著性差异（p〈0.05）、且血清IL-2水平与VEGF水平呈正相关（r=0.5134p〈0.01）,而与IL-4呈高度负相关（r=0.6012p〈0.01）,结论：检测再生障碍性贫血患者血清IL-2、IL-4和VEGF水平的变化对于了解病情,观察疗效和预后判断均具有重要的临床价值.

Objective：To explore the climical significance of serum IL-2、IL-4 and VEGF levels after treatment in patients with aplastic anemia .Methods：Serum IL-2、IL-4 and VEGF（with ELISA） levels were measured in 31 patients with aplastic anemia as well as in 35 controls. Resullts：Before treatment ,serum IL-2、VEGF levels were significantly lower than those in controls （p〈0.01）,but IL-4 levels were significantly highly（p〈0.05）,after treatment for 3months. The levels though dropped markedly ,but remained apparently higher than those in controls serum IL-2 levels was positively correlated with serum VEGF levels（r=0.5134 p〈0.01）,but serum IL-2 levels was negatively correlated with serum IL-4 levels（r=0.6012 p〈0.01）.Conclusiongs： detection of Serum IL-2, IL-4 and VEGF levels can he useful for prediction of therapeutic efficancy and prognosis in patients with aplastic anemia and bence provides defimite clinical values.