KI67,P16在宫颈癌中的研究

宫颈癌大多都是逐渐发展来的,由宫颈癌癌前病变转变而来.如果引起重视,是完全可以逆转的.单一的细胞学检查和病理筛查还不能完全评价女性得宫颈癌的概率,探讨宫颈癌的筛查的其它方法.方法免疫组织化学法,对68例标本进行检测,分析比较 ki67、P16的表达在各种宫颈组织的情况.结果每个分组的结果有显着性差异.结论宫颈级别增加,ki67也呈现增强趋势.P16蛋白的表达也呈现增强趋势.ki67、P16共同表达可以作为宫颈癌的检测指标,也用于宫颈癌的早期诊断和预防.

Objective Most of the cervical cancer is gradually developed, and it is changed from the precancerous lesion of cervical cancer. If attention is paid, it can be reversed. Single cytology and pathological screening can not completely evaluate the probability of cervical cancer in women, to explore other approachs of screening for cervical cancer. Methods Immunohistochemical approach was performed to detect the expression of Ki67 and P16 in all kinds of cervical tissues in 68 cases. Result There were significant differences in the outcomings of each subgroup. Conclusion Cervical levels increased, Ki67 also showed a trend of enhancement. The expression of P16 protein also showed an enhanced trend. P16, Ki67 co expression can be used as the detection index of cervical cancer, but also for the early diagnosis and prevention of cervical cancer.