脑梗死患者急性期hs-CRP、IL-6和IL-18水平检测的临床意义

目的：探讨了脑梗死患者急性期hs-CRP,IL-6和 IL-18水平的变化及临床意义.方法 ：应用免疫比法和酶联法对36例脑梗死患者进行了血清hs-CRP,IL-6和 IL-18水平的变化,并与35名正常健康人作比较.结果 ：脑梗死患者急性期 hs-CRP,IL-6和 IL-18水平都非常显著地高于正常人组（p〈0.01）,且 hs-CRP 水平与 IL-6和 IL-18水平呈显著正相关（r=0.4728,0.5134,p〈0.01）.结论：检测脑梗死患者急性期的hs-CRP,IL-6和IL-18水平的变化与疾病的发生和发展密切相关生、发展与血清IL-2、IL-6和VEGF水平密切相关.

Objective： To explore the clinical significance of changes of serum hs-CRP,IL-6 和IL-18 in patients with acute cerebral infarction.Methods： Serum hs-CRP（with immune arbilitity approach） Serum IL-6,IL-18 （with ElISA） levels were measured in 36 patients with acute cerebral infarction and 35 controls. Results： Serum hs-CRP,IL-6 and IL-18 levels were significantly higher than those in controls （P〈0. 01）, Serum hs-CRP levels were positively corrected with IL-6,IL-18 levels （r=0.4728,0.5134,p〈0.01）. Conclusions： Detection of serum hs-CRP,IL-6 and IL-18 levels might be of prognostic in portance in patients with acute cerebral infarction.