再生障碍性贫血患者T细胞亚群和血清IL-2、IL-18水平检测的临床意义

目的：分析观察再生障碍性贫血（aplastic anemia,AA）患者外周血中 T 细胞亚群表达情况和血清中白介素-2（interleukin-2,IL-2）、白介素18（interleukin-18,IL-18）表达量,并探讨其检测的临床意义.方法：应用流式细胞仪检测法和酶联法对30例AA患者进行了T细胞亚群和血清IL-2、IL-18水平检测,同期与30例健康体检者作比较.结果：AA 患者组 CD3、CD4、CD4/CD8较健康体检组均降低,且具有统计学意义（P〈0.01）,CD8水平升高,IL-2、IL-18水平升高,都具有统计学意义（P〈0.01）,CD3水平与 IL-2水平呈显著负相关（r=-0.6018,P〈0.01）.结论：检测 T细胞亚群和血清 IL-2、IL-18水平的变化对判断 AA 病情、监测疗效均有重要的临床价值.

Objective To explore the clinical significance of change of T-Lymphocyte Subgroup and Serum IL-2、IL-18 levels in patients with aplastic anemia. Methods： T-Subgroup（with monocolon antibody serum IL-2、IL-18（with Elisa） levels were determined in 30 cases with aplastic anemia and 30 controls . Results： CD3、CD4、CD4/CD8 lower than those in cintrols（P〈0.01）.but CD8Higher than those in controls （P〈0.01）. IL-2、IL-18 levels were significance of higher than these in controls（P〈0.01）、CD3 lower than negatively correlated with serum IL-2 levels （r=-0.6018,P〈0.01）.Conclusions： detection of T-subgroup and serum IL-2、IL-18 levels were helpful for the prediction of treatment efficacy in patient with aplastic anemia , must be of clinical values.