黏蛋白MUC5ac在肺鳞癌、腺癌中的表达及临床意义

目的探讨黏蛋白 MUC5ac 在肺鳞癌、腺癌中的表达及其与临床病理参数之间的关系.方法应用免疫组织化学方法对57例肺鳞癌、腺癌进行黏蛋白 MUC5ac 检测.结果57例肺鳞癌、腺癌中 MUC5ac 的阳性表达率为73.68%（42/57）.其中在肺鳞癌的阳性率为76.09%（35/46）;肺腺癌的阳性率为63.64%（7/11）;MUC5ac 在肺鳞癌、腺癌中的表达与患者性别、年龄、组织学分型、细胞分化程度均无明显地统计学差异（P〉0.05）;与吸烟（吸烟指数〉400）、淋巴结转移、临床分期有明显统计学相关性（P值〈0.05）.结论MUC5ac 在肺鳞癌、腺癌中高表达;MUC5ac 可以作为判断肺鳞癌、腺癌的细胞起源、肿瘤良恶性及恶性程度和预后的有价值检测指标.

OBJECTIVE： To investigate the relationship between mucin MUC5ac lung squamous cell carcinoma and adenocarcinoma of expression and clinicopathological parameters.Methods The immunohistochemical approach in 57 cases of lung squamous cell carcinoma, adenocarcinoma mucin MUC5ac testing. Results 57 cases of lung squamous cell carcinoma, adenocarcinoma MUC5ac positive expression rate of 73.68% （42/57）. Wherein the positive rate of lung squamous cell carcinoma of 76.09% （35/46）; the positive rate of lung adenocarcinoma 63.64% （7/11）; MUC5ac with gender expression in squamous cell carcinoma, adenocarcinoma, age, organization typing, cell differentiation were not significantly statistical difference （P〉 0.05）; and smoking （smoking index〉 400）, lymph node metastasis, clinical stage statistically significant correlation （P 〈0.05）. Conclusion MUC5ac in squamous cell carcinoma, adenocarcinoma of expression;MUC5ac can determine the lung squamous cell carcinoma, adenocarcinoma cell origin, benign and malignant tumors and malignant degree and prognosis of valuable detected.