慢性心衰患者病程中的NT-proBNP水平的变化

目的：探讨慢性心衰患者病程中血浆 N 末端 B 型利钠肽原（NT-proBNP）水平的变化.方法：随机入选180例慢性心力衰竭患者,其中Ⅲ、Ⅳ级各90例,入组后24小时内及症状缓解后均测定 NT-proBNP、心脏超声（左心室内径 及左心功能EF 值）等,分析慢性心衰患者病程中NT-proBNP 的水平变化.结果：研究发现 NYHA Ⅳa 级患者治疗前的 NT-proBNP 水平明显高于NYHA Ⅲ级患者,症状缓解后水平均明显下降,差异有统计学意义.但 NYHA Ⅳb 级患者的 NT-proBNP 水平较NYHA Ⅲ级、NYHA Ⅳa 级患者不升反降,差异有统计学意义 .结论：NT-proBNP 水平对慢性心衰患者的病情分级及预后评估有重要的指导意义.

objective： To investigate the Changes of N terminal B type natriuretic peptide （NT-proBNP） levels in the course of the patients with chronic heart failure disease .methods： Randomly selected 180 cases of patients with chronic heart failure, With 90 cases Ⅲ,90 Ⅳ level, NT-proBNP, cardiac ultrasound （left ventricular inner diameter and left ventricular function EF value） were measured in 24 hours after the entry and symptom relief. Analysis of the level of NT-proBNP in patients with chronic heart failure.Results： NT-proBNP level of NYHA class Ⅳa patients before treatment was significantly higher than that of NYHA grade Ⅲ patients,Levels were significantly decreased after symptoms,The difference was statistically significant. But the level of I NT-proBNP in patients with NYHA Ⅳb than NYHA Iva patients not up and down,The difference was statistically significant.Conclusion： NT- ProBNP levels have important guiding significance for the assessment of the severity and prognosis of patients with chronic heart failure.