5-FU与洛铂对原发性肝癌晚期患者血清AFP及TIP30水平的影响

The effect of 5-FU and lobaplatin in the treatment of advanced hepatocellular carcinoma in serum AFP and TIP30

目的探讨5-氟尿嘧啶（5-FU）与洛铂（LBP）治疗原发性肝癌晚期患者血清甲胎蛋白（alpha fetoprotein,AFP）及TIP30（tat interacting protein 30）水平的影响及意义。方法选取2014年6月-2016年6月于宁夏医科大学总医院以原发性肝癌晚期为诊断入院的患者86例,随机分为2组,对照组43例,予微导管缓慢序贯灌注5-FU治疗;实验组43例,在对照组相同的常规治疗基础上,予微导管缓慢序贯灌注洛铂治疗。观察2组患者治疗前后血清AFP、甲胎蛋白异质体（AFP-L3）、铁蛋白（Fer）、恶性肿瘤特异生长因子（tumor specific growth fanctor,TSGF）、TIP30水平、临床疗效和不良反应。结果与治疗前比较,2组患者治疗后的AFP-L3、Fer、TSGF和AFP水平均降低,TIP30水平均升高（P〈0.05）;治疗后2组同期比较,实验组的AFP-L3、Fer、TSGF和AFP水平均低于对照组,TIP30水平均升高（P〈0.05）;实验组总有效率高于对照组,实验组不良反应发生率低于对照组,以上结果差异均有统计学意义（P〈0.05）。结论洛铂能有效降低原发性肝癌晚期患者血清AFP、AFP-L3、Fer、TSGF水平,提高TIP30水平。

Objective To investigate the effect of 5-FU and Lobaplatin in the treatment of advanced hepatocellular carcinoma in serum AFP and TIP30. Methods 86 cases of advanced hepatocellular carcinoma in our hospital form June 2014 to June 2016 were selected and randomly divided into two groups,43 cases in the control group were treated with micro catheter perfusion 5-FU sequential therapy,43 cases in the experimental group were treated more with Lobaplatin sequential therapy. The serum levels of AFP,AFP-L3,Fer,TSGF,TIP30,clinical efficacy and adverse reactions were compared before and after treatment in the two groups. Results Compared with before treatment,levels of AFP-L3,Fer,TSGF and AFP decreased in two groups,levels of TIP30 increased（ P〈0. 05）; compared with the control group,levels of AFP-L3,Fer,TSGFand AFP in the experimental group were lower（ P〈0. 05）,and levels of TIP30 were higher（ P〈0. 05）,and the total efficiency of the experimental group was higher than the control group（ P〈0. 05）,and the incidence of adverse reactions in the experimental group was lower than the control group（ P〈0. 05）. Conclusion 5-FU and Lobaplatin in the treatment of advanced hepatocellular carcinoman can effective reduce the levels of AFP,AFP-L3,Fer,TSGF,and increased the levels of TIP30.