益脾柔肝方联合化疗对中晚期原发性肝癌患者疗效及生存质量的影响

Effect of Yipi Rougan recipe comined chemotherapy on quality of life in intermediated or advanced-staged primary hepatic carcinoma and its efficacy

目的探讨益脾柔肝方联合化疗对中晚期原发性肝癌患者疗效及生存质量的影响。方法选取2013年4月-2015年12月在台州市立医院胃肠外科进行诊治的97例中晚期原发性肝癌患者作为研究对象,采用抽签法随机分为中医组48例和单纯化疗组49例,2组均给予肝动脉介入栓塞化疗,中医组同时给予益脾柔肝方进行辅助治疗,21d为1个疗程,共计完成4个疗程。结果中医组的化疗总有效率与单纯化疗组比较差异不具统计学意义（83.33%vs.77.55%）;治疗后,中医组的生活质量（quality of life,QOL）评分、行为状态评分（Karnofsky performance score,KPS）高于单纯化疗组,差异具有统计学意义（P〈0.05）;治疗后,中医组的各项中医症候积分低于单纯化疗组,差异具有统计学意义（P〈0.05）。结论益脾柔肝方联合化疗对中晚期原发性肝癌患者的化疗效果影响不显著,但是可以显著的缓解患者的临床症状、提高患者的生存质量。

Objective To investigate the effect of Yipi Rougan recipe comined chemotherapy on quality of life in the treatment of patients with intermediated or advanced-staged primary hepatic carcinoma and its efficacy. Methods From April 2013 to December 2015 in our hospital,97 patients with advanced primary liver cancer patients were selected,and randomly divided into traditional Chinese medicine group of 48 patients and chemotherapy group of 49 patients,two groups were treated with transcatheter arterial embolization chemotherapy,while the traditional Chinese medicine group were given Yipi Rougan recipe adjuvant therapy,21 days for a course of treatment,with a total of four courses. Results There was no significant difference in total effective rate between traditional Chinese medicine group and chemotherapy group（ 83. 33% vs. 77. 55%）. After treatment,the quality of life（ QOL） score,Karnofsky performance score（ KPS） in traditional Chinese medicine group were higher than those in chemotherapy group（ P〈0. 05）.The each symptom score in traditional Chinese medicine group was lower than that in chemotherapy group（ P〈0. 05）. Conclusion The efficacy of Yipi Rougan recipe combined with chemotherapy is not significant on patients with intermediated or advanced-staged primary liver cancer chemotherapy,but can significantly relieve symptoms and improve the quality of life of patients.