心脉隆注射液联合芪苈强心胶囊对老年慢性心力衰竭患者血清BNP、NF-κB及CysC的影响

Effect of Xinmailong injection combined with Qiliqiangxin capsule on serum BNP,NF-kappa B and cystatin C in elderly chronic heart failure

目的探讨心脉隆注射液联合芪苈强心胶囊对老年慢性心力衰竭(chronic heart failure,CHF)患者血清B型钠尿肽(Btype natriuretic peptide,BNP)、NF-κB及胱抑素C(cystatin c,CysC)水平的影响。方法研究对象为78例老年慢性心力衰竭患者,依据随机数字表法分成2组,每组39例。均接受一般基础治疗,对照组予以西医标准治疗方案,研究组在上述基础上再予以心脉隆注射液联合芪苈强心胶囊治疗,测定治疗前后BNP、CysC以及NF-κB水平,检测左心室功能以及6 min步行试验的变化,比较临床疗效。结果与治疗前比较,2组BNP、CysC、NF-κB水平均降低(P<0.01),左心射血分数(left ventricular ejection fraction,LVEF)升高(P<0.05),左心室收缩末期容积(left ventricular end-systolic volume,LVESV)降低(P<0.05),6 min步行距离升高(P<0.01),中医症候积分降低(P<0.01);与对照组比较,研究组BNP、CysC、NF-κB水平较低(P<0.01),LVEF较高(P<0.05),左心室舒张末期容积(left ventricular end-diastolic volume,LVEDV)、LVESV较低(P<0.05),6 min步行距离较高(P<0.01),中医症候积分较低(P<0.01),治疗有效率较高(P<0.05)。结论心脉隆注射液联合芪苈强心胶囊治疗老年慢性心力衰竭疗效显著,明显改善左心功能,可能机制与降低BNP、CysC以及NF-κB水平密切相关。

Objective To investigate the effect of Xinmailong injection combined with Qiliqiangxin capsule on serum BNP,NF- kappa B and cystatin C in the treatment of chronic heart failure in the elderly. Methods 78 cases of elderly patients with chronic heart failure were selected and randomly divided into two groups according to the random number table,39 cases in each group. All patients received basic treatment,the control group received standard treatment,and the study group received more with Xinmailong injection combined with Qiliqiangxin capsule,and levels of serum B-type natriuretic peptide（ BNP）,cystatin C（ CysC） and NF-κB were compared,left ventricular function and 6 min walking test were detected and the clinical curative effect were compared after the treatment. Results Compared with before treatment,levels of serum BNP,CysC and NF-κB in 2 groups decreased（ P〈0. 01）,left ventricular ejection fraction（ LVEF） increased（ P〈0. 05）,left ventricular end-systolic volume（ LVESV） reduced（ P〈0. 05）,6 min walking distance increased（ P〈0. 01）,scores of symptom decreased（ P〈0. 01）,compared with the control group,levels of serum BNP,CysC and NF-κB in study group were lower,LVEF were higher（ P〈0. 05）,levels of LVEDV and LVESV were lower（ P〈0. 05）,scores of 6 min walking distance were higher（ P〈0. 01）,scores of symptom were lower（ P〈0. 01）,the effective rate was higher（ P〈0. 05）. Conclusion Xinmailong injection combined with Qiliqiangxin capsule in the treatment of chronic heart failure in the elderly was effective,and it can improve left ventricular function,the possible mechanism related to the decrease of BNP,CysC and NF-κB levels.