参芪扶正注射液对糖尿病患者T淋巴细胞亚群及氧化应激水平的影响

Effects of Shenqifuzheng injection on T-cell subsets and oxidative stress in patients with diabetes mellitus

目的探讨参芪扶正注射液对糖尿病患者T淋巴细胞亚群及氧化应激水平的影响。方法选取2015年6月-2016年6月杭钢医院诊断为2型糖尿病患者90例,随机分为对照组和观察组,各45例。对照组给予常规治疗,观察组在对照组基础上给予参芪扶正注射液。观察比较2组患者外周血T细胞亚群及血清中氧化应激代谢产物谷胱甘肽过氧化物酶（glutathione peroxidase,GSH-PX）、超氧化物歧化酶（superoxide dismutase,SOD）、过氧化氢酶（catalase,CAT）水平及患者血糖控制情况。结果治疗后,对照组T淋巴细胞亚群Th17、Treg及Th17/Treg水平与治疗前比较无显著差异,观察组Th17、Th17/Treg水平均显著降低且低于对照组（P〈0.05）,Treg含量显著升高且高于对照组（P〈0.05）;治疗后,观察组CAT水平低于对照组,GSH-PX、SOD水平高于对照组,差异均具有统计学意义（P〈0.05）;治疗后,观察组患者GLU、2h PG、HOMA-IR、Hb A1C（%）与治疗前相比均明显降低,且低于对照组（P〈0.05）。结论参芪扶正注射液能有效改善糖尿病患者T细胞亚群和氧化应激水平,有助于控制血糖。

Objective To investigate the effects of Shenqifuzheng injection on T-cell subsets and oxidative stress in patients with diabetes mellitus.Methods 90 cases of 2 diabetes patients from June 2015 to June 2016 in our hospital were selected and randomly divided into control group and observation group,45 cases in each group,the control group treated with conventional treatment,the observation group was given Shenqifuzheng injection based on the control group. The levels of peripheral blood T cell subsets,serum oxidative stress metabolites glutathione peroxidase,superoxide dismutase and catalase,the control of blood glucose were compared between the two groups. Results After treatment,the levels of Th17,Treg and Th17/Treg in control group compared with before treatment had no significant difference,the levels of Th17 and Th17/Treg in observation group were obviously decreased and lower than in control group（ P〈0. 05）; the content of Treg in observation group was increased significantly and higher than the control group（ P〈0. 05）. After treatment,the levels of CAT in observation group was lower than control group,GSH-PX and SOD were higher than control group,the difference was statistically significant（ P〈0. 05）. After treatment,the GLU,2h PG,HOMA-IR and Hb A1C（ %） in observation group were significantly decreased than before treatment and lower that in control group,the difference was statistically significant（ P〈0. 05）.Conclusion Shenqifuzheng injection can effectively improve the T cell subsets and oxidative stress levels in diabetic patients,help to control blood sugar.