骨碎补注射液对骨折延迟愈合患者的临床疗效

Clinical efficacy on drynaria injection for delayed healing of fracture patients

目的探讨骨碎补注射液对骨折延迟愈合患者的临床研究。方法选取2010年2月-2016年2月浙江省台州市恩泽医疗中心路桥医院收治的骨折延迟愈合患者108例,根据治疗方法的不同,随机分为2组,每组各54例,对照组予以常规治疗,实验组在对照组的基础上予以骨碎补注射液治疗。治疗后,观察并比较2组患者的总有效率,血清碱性磷酸酶、神经生长因子（nerve growth factor,NGF）及骨形态发生蛋白2（bone morphogenetic protein 2,BMP-2）水平。结果治疗后,实验组的总有效率显著高于对照组（P〈0.05）;治疗7、14 d后,2组患者的血清碱性磷酸酶与治疗前相比均显著升高（P〈0.05）,与对照组比较,实验组血清碱性磷酸酶含量较高（P〈0.05）;治疗7、14 d后,2组患者的血清NGF和BMP-2水平显著升高（P〈0.05）;与对照组比较,实验组血清NGF和BMP-2水平较高（P〈0.05）。结论骨碎补注射液治疗骨折延迟愈合患者效果显著,提高血清碱性磷酸酶、血清NGF和BMP-2含量,促进患者骨折愈合,提高临床疗效。

Objective To investigate the clinical study on drynaria injection for delayed healing of fracture patients. Methods 108 patients with fracture delayed union from February 2010 to February 2016 in our hospital were selected and randomly divided into the control group and the experiment group by different treatment,54 cases in each group. The control group were treated by conventional therapy,the experiment group were treated with drynaria rhizome injection on the bases of control group. The total effective rate,serum alkaline phosphatase,NGF and BMP-2 levels were observed and compared after treatment. Results After treatment,the total effective rate of experiment group was higher than control group（ P〈0. 05）; After treatment for 7 and 14 days,the serum alkaline phosphatase level of the two groups were significantly increased（ P〈0. 05）,and compared with the control group,the serum alkaline phosphatase content of the experimental group was higher（ P〈0. 05）; After treatment for 7 and 14 days,the serum NGF and BMP-2levels of two groups were significantly increased（ P〈0. 05）,and compared with the control group,the experimental group was higher than those in the control group. Conclusion Injection of rhizoma drynariae in the treatment of delayed healing of patients with significant effect,increase the levels of serum alkaline phosphatase,serum NGF and BMP-2,promote fracture healing in patients and improve clinical efficacy.