脂肪肝和丙肝病毒(HCV)感染发病的相关性研究

Fatty Liver and Hepatitis C Virus(HCV) Infection in the Pathogenesis of Num Tip

目的分析脂肪肝和丙肝病毒(HCV)感染之间的影响和具有的相关性。方法整群选取该院自2015年8月—2016年2月期间收治的165例脂肪肝患者定为观察组,选取同时期165名体检情况健康的正常人为对照组,然后对比两组在HCV感染方面的差异。结果观察组165例患者共检测出抗HCV阳性19例(11.5%),其中血清标本同时伴有HCVRNA12例(7.3%);均明显高于对照组,两组患者的HCV二项指标(抗HCV和HCVRNA)阳性率对比,差异有统计学意义(P﹤0.05)。将19例合并HCV感染的脂肪肝患者,与63例单纯脂肪肝患者的HDL-C、AST、及CH、ALT和TG等血清生化指标的情况进行了对比,差异无统计学意义。但是丙肝合并脂肪肝患者的ALT值要高于单纯脂肪肝患者。结论脂肪肝和HCV感染有着十分密切的关系,在一定情况下,HCV感染会引起脂肪肝,而且可以发现,在慢性HCV感染患者发展成为肝硬化的过程中,通常都会经历脂肪肝这一前期过渡阶段,故应当对HCV感染加以控制预防,有着重要的意义。

Objective Analysis of fatty liver and hepatitis C virus（HCV） infection and the correlation between them.Methods Group selection our hospital from August 2015 to February 2016 were 165 fatty liver patients as the observation group, select the same period 165 cases of healthy physical examination of the normal control group, and then compared the two groups in the different aspects of HCV infection. Results The 165 observation group patients were detected in 19 anti HCV positive cases（11.5%）, the serum samples with HCVRNA12（7.3% cases）; were significantly higher than the control group, the two indicators of the two groups of patients HCV（anti HCV and HCVRNA） positive rate comparison, there are obvious differences（P〈0.05）, with statistical significance, HDL-C, and AST, CH,, ALT and TG serum biochemical indexes of 63 patients with HCV infection were compared with other serum biochemical indexes, the difference was not statistically significant. But hepatitis C patients with nonalcoholic fatty liver ALT values were higher than that of pure fatty liver. Conclusion Fatty liver and HCV infection are closely related, in certain cases, HCV infection can cause fatty liver, and it can be found in patients with chronic HCV infection develop cirrhosis of the liver in the process, usually through the early transition stage of fatty liver, it should be on the prevention and control of HCV infection, a important.