尼麦角林联合臭氧大自血灌注治疗脑梗死后认知功能障碍的疗效分析

Clinical Effect of Nicergoline and Ozone Therapy in the Reatment of Cogni-tive Disorder after Cerebral Infarction

目的探讨脑梗死后认知功能障碍采用尼麦角林联合臭氧大自血灌注治疗的疗效。方法方便选取90例于2013年5月—2014年5月期间该院接收的急性脑梗死患者,随机分为对照组(尼麦角林治疗,n=45)和实验组(尼麦角林+臭氧大自血灌注治疗,n=45),观察两组认知功能评分及血流速度在治疗前后的变化。结果两组用药后,MMSE、WMS、Mo CA分值均有明显提高(P<0.05),P300潜伏期分值均明显下降(P<0.05),而相比于对照组的上述指标,分别为(20.18±2.36)、(43.18±2.56)、(21.05±2.63)、(300.15±38.54)分,实验组改善较为明显(P<0.05),分别为(24.35±2.56)、(48.33±2.85)、(25.71±2.54)、(254.32±46.85)分;用药后,实验组血流速度显著提高,LMCA、LACA、RMCA、RACA分别为(81.1±10.6)、(57.8±8.3)、(88.4±11.1)、(62.1±9.6),对照组明显下降(P<0.05),分别为(54.5±13.3)、(33.7±8.6)、(54.2±11.8)、(34.1±5.9),组间比较差异有统计学意义(P<0.05)。结论脑梗死后认知功能障碍采用尼麦角林联合臭氧大自血灌注治疗,可显著提高脑血流量,提高认知功能,具有推广价值。

Objective To study the clinical effect of Nicergoline and Ozone therapy in the treatment of cognitive disorder after cerebral infarction. Methods Convenient selection 90 patients with acute cerebral infarction treated from May 2013 to May 2014 in our hospital were selected. The subjects were randomly divided into two groups, 45 cases each group. The control group adopted Nicergoline; the test group adopted the Nicergoline and Ozone therapy. The changes of cognitive function and blood flow velocity in the two groups before and after treatment were observed. Results After treatment, the points of MMSE, WMS and Mo CA for two groups were greatly increased（P〈0.05）; the point of P300 latency was greatly reduced（P〈0.05）; t Respectively, and group was done by improving and compared to the control group of the above indexes,respectively（20.18±2.36）,（43.18±2.56）,（21.05±2.63）,（300.15±38.54）posuts, experimental obvious（P〈0.05）, respectively（24.35±2.56）,（48.33±2.85）,（25.71±2.54）,（254.32±46.85 posuts; medication, the experimental group, the blood flow velocity significantly increased LMCA, LACA rmca Raca（81.1 ±10.6）,（57.8 ±8.3）,（88.4 ±11.1）,（62.1 ±9.6）, the control group decreased significantly（P〈 0.05）, respectively（54.5 ±13.3）,（33.7 ±8.6）,（54.2 ±11.8）,（34.1 ±5.9）, the group had significant difference（P 〈0.05）.Conclusion For cerebral infarction patients complicated with cognitive disorder, Nicergoline and Ozone therapy can improve the cerebral blood flow and cognitive function. It is worthy of promotion.