摘要
目的通过对孕妇甲状腺功能及甲状腺过氧化物酶抗体(TPOAb)的测定,探讨血TPOAb阳性对孕妇妊娠结局的影响。方法选取2015年1月至2015年12月来苏州市立医院建卡的250例孕妇作为研究对象,根据TPOAb滴度分为TPOAb阳性组和TPOAb阴性组。比较两组孕妇的血清甲状腺激素水平、妊娠结局和新生儿并发症的发生率。结果 250例患者中,TPOAb阳性者87例,TPOAb阴性组163例,两组甲状腺激素水平差异有统计学意义(P<0.05)。TPOAb阳性组孕妇合并胎儿窘迫11例(12.64%),早产10例(11.49%),其发生率明显高于TPOAb阴性组,差异有统计学意义(P<0.05)。TPOAb阳性组孕妇合并妊娠期糖尿病、妊娠期高血压疾病、胎膜早破的发生率稍高于TPOAb阴性组,差异无统计学意义(P>0.05)。TPOAb阳性组低出生体重儿、新生儿窒息、死胎、新生儿甲减发生率明显高于TPOAb阴性组,差异有统计学意义(P<0.05)。两组胎儿畸形发生率差异无统计学意义(P>0.05)。结论妊娠期的TPOAb对妊娠期亚临床甲状腺功能减退的诊断和妊娠结局的判断具有一定的意义。
Objective To investigate the effect of TPOAb positive blood on pregnancy outcome in pregnant women by measuring thyroid function and thyroid peroxidase antibody（TPOAb）.Methods From January 2015 to December 2015,200 gravidas regularly checked were chosen as objectives,and were divided into TPOAb positive group and TPOAb negative group according TPOAb.The level of thyroid hormone,pregnancy outcome,and complication of neophyte between two groups were compared.Results In 200 gravidas,87were positive in TPOAb and 163 were negative.The level of thyroid hormone between two groups had statistical difference（P〈0.05）.The incidence of fetal distress in uterus（12.64%）and premature delivery（6.90%）of the TPOAb positive group was higher than that of the TPOAb negative group,the differences were statistically significant（P〉0.05）.The incidence of pregnancy-induced hypertension,gestational diabetes mellitus and premature rupture of fetal membrane had no statistical difference between the two groups（P〈0.05）.The incidence of low weight fetus,neonatal asphyxia,stillbirth and neonatal hypothyroidism of the TPOAb positive group were higher than those of the TPOAb negative group,the differences were statistically significant（P〉0.05）.The incidence of fetal malformation had no statistical difference between the two groups（P〉0.05）.Conclusion During gestation period,the TPOAb is significant for the diagnosis of the subclinical hypothyroidism,as well for prognosis of gravidas.
出处
《青岛医药卫生》
2016年第6期411-414,共4页
Qingdao Medical Journal
